Add time:08/23/2019         Source:sciencedirect.com

A new strategy for the synthesis of oxide-containing fragments of morphine has been developed. Thus, the tricyclic (ANO) morphine fragment spiro[7-methoxybenzofuran-3(2H),4′-1′-methylpiperidine] (1) was obtained as the sole product via an intramolecular radical cyclization of 4-[(2′-bromo-6′-methoxyphenoxy)methyl]-1-methyl-1,2,5,6,-tetrahydropyridine (9); while the tetracyclic (ACNO) fragment 9-methoxy-3-methyl-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuro[3,2-e]isoquinoline (3) and its 4-oxo analog 4 were synthesized in a similar fashion starting from 5,6,7,8-tetrahydroisoquinoline (10).

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