Add time:08/25/2019         Source:sciencedirect.com

A one-pot synthesis of 1-hydroxymethyl-3-aminomethyl indoles 3 could be achieved in excellent yield by reacting indoles 1 with formaldehyde and secondary amines 2 in the presence of molecular sieves (3 Å) and catalytic amount of InCl3 (10 mol %) in 1,4-dioxane at room temperature for 3–5 h.

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