Add time:08/23/2019         Source:sciencedirect.com

In the present study, a wide variety of 3-{[(1, 3-benzoxazol-2-yl) sulfanyl] (phenyl) methyl}-4-hydroxy-2H-1-benzopyran-2-one derivatives were synthesized through one-pot three-component reaction using 4-hydroxy coumarin, 2-mercapto benzoxazole and substituted aldehydes in presence of L-proline as a catalyst. The reaction involves Knoevenagel condensation of 4-hydroxy coumarin with an aldehyde followed by nucleophilic addition to the intermediate via conjugate addition to carbonyl compounds. The structural conformation of synthesized compounds was done by different spectroscopic techniques. Further, all the compounds were screened for their biological applications.

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