Add time:08/29/2019         Source:sciencedirect.com

Radiolabeled amino acids represent a promising class of tumor imaging agents, and the determination of the optimal characteristics of these tracers remains an area of active investigation. A new 18F-labeled branched amino acid, 2-amino-4-[18F]fluoro-2-methylbutanoic acid (FAMB), has been prepared in 36% decay-corrected yield using no-carrier-added [18F]fluoride. In vitro uptake assays with rat 9L gliosarcoma cells suggest that [18F]FAMB was transported primarily via the L type amino acid transport system. In vivo studies with [18F]FAMB demonstrated tumor to normal brain ratios of 14:1 in rats with intracranial 9L gliosarcoma tumors at 60 minutes after injection. Comparison of [18F]FAMB with structurally related 18F-labeled branched amino acids demonstrated that A type transport in vitro was positively correlated with the tumor to brain ratios observed in vivo.

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