Replication of mitochondrial DNA: Selective inhibition of the H-strand synthesis in isolated mitochondria by sibiromycin-Science-Chemical Encyclopedia-lookchem

Replication of mitochondrial DNA: Selective inhibition of the H-strand synthesis in isolated mitochondria by Sibiromycin (cas 12684-33-2)
Add time:08/27/2019 Source:sciencedirect.com

Sibiromycin, an antitumour antibiotic forming a stable complex with the double-stranded DNA selectively inhibits the incorporation of [3H]thymidine into the H-strand of mtDNA during the incubation of isolated rat liver mitochondria in vitro. A model accounting for this result is presented. It is concluded that the H-strand is a leading strand throughout mtDNA replication and consequently the replication of rat liver monomer mtDNA is unidirectional.

We also recommend Trading Suppliers and Manufacturers of Sibiromycin (cas 12684-33-2). Pls Click Website Link as below: cas 12684-33-2 suppliers

Prev:Pyrrolo(1,4)benzodiazepine antitumor antibiotics In vitro interaction of anthramycin, Sibiromycin (cas 12684-33-2) and tomaymycin with DNA using specifically radiolabelled molecules
Next: Raman and infrared spectroscopic evidence for the structural changes of the 2Fe2S cluster and its environment during the interaction of Adrenodoxin (cas 12687-22-8) and Adrenodoxin (cas 12687-22-8) reductase)

Click to view details

Encyclopedia