The effect of bacitracin and Ca++ on the formation of polyprenylpyrophosphates and their incorporation into ubiquinone precursors in mammalian and bacterial systems-Science-Chemical Encyclopedia-lookchem

The effect of bacitracin and Ca++ on the formation of polyprenylpyrophosphate (cas 38095-90-8)s and their incorporation into ubiquinone precursors in mammalian and bacterial systems
Add time:07/14/2019 Source:sciencedirect.com

Formation of ubiquinone precursors, polyprenylpyrophosphate, and 3-polyprenyl-4-hydroxybenzoic acid is greatly inhibited by bacitracin. The antibiotic prevents the transfer of polyprenylpyrophosphate to p-hydroxybenzoic acid in rat liver mitochondria and in cell-free extracts of Rhodospirillum rubrum. In extracts of Micrococcus lysodeikticus bacitracin also inhibits the polymerization of isopentenylpyrophosphate to the longer chain polyprenylpyrophosphates. Ca++ also inhibits the formation of polyprenylpyrophosphate and 3-polyprenyl-4-hydroxybenzoate in rat liver mitochondria. The significance of agents which influence the availability of polyprenylpyrophosphate in synthetic pathways is discussed.

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