New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents-Science-Chemical Encyclopedia-lookchem

New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents
Add time:07/13/2019 Source:sciencedirect.com

A facile synthetic approach to 5-arylamino-4-(5-nitrofuran- 2-yl)pyrimidines by the Buchwald–Hartwig cross-coupling with various anilines has been developed. All synthesized compounds demonstrated a significant level of in vitro antibacterial activity against Neisseria gonorrhoeae, Streptococcus pyogene and Staphylococcus aureus, including their drug-resistant strains, which is much higher than that of the commercial drug Spectinomycin.

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