Add time:08/24/2019         Source:sciencedirect.com

We report the hypersensitivity of SV40-transformed fibroblasts derived from ataxia telangiectasia (AT) patients to calicheamicin γ1I. In common with other free-radical generating agents such as bleomycin and ionizing radiation, treatment with calicheamicin γ1I reveals AT derived lines to be 6-fold more sensitive to this drug when compared to controls. Furthermore, in common with ionizing radiation, AT cells did not show dose-dependent inhibition of DNA synthesis after treatment with calicheamicin γ1I

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