Add time:08/24/2019         Source:sciencedirect.com

The novel purine and pyrimidine nucleoside analogues possessing a 2,3-epoxypropyl (2a–2c and 8a–8c), 2,3-epoxypropyl ether (3), or 3-amino-2-hydroxypropyl (4a–6c and 9a–9c) moiety bonded at either N-9 of the C-6 substituted purine ring or N-1 and N-3 of the pyrimidine ring, were prepared and evaluated on their antitumour and antiviral activities. Compounds 3, 6b, 8b and 8c showed marked inhibition of growth of human tumour cell lines (MiaPaCa2 and Raji), whilst the inhibitory effect of 6b was greater against Raji cells than to the MiaPaCa2 ones. No specific activity of compounds 2a–3, 4a–6c and 9a–9c against HSV and VZV was detected. The compound 6b was slightly active against the replication of HIV 1 (IIIB), while 2a-2c and 8a-8c were inactive.

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