Add time:08/24/2019         Source:sciencedirect.com

Structure–activity relationship studies performed around 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile for the purpose of developing novel mGlu5 receptor antagonists are described. Synthesis of a series of four-ring tetrazoles led to the discovery of 3-[3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine, a highly potent, brain penetrant, azole-based mGlu5 receptor antagonist.

We also recommend Trading Suppliers and Manufacturers of (5-PYRIDIN-4-YL-TETRAZOL-2-YL)-ACETIC ACID (cas 132766-78-0). Pls Click Website Link as below: cas 132766-78-0 suppliers