Add time:08/24/2019         Source:sciencedirect.com

Two new and versatile synthetic methods for preparing 5-nitro-analogues of HEPT and MKC-442 which are HIV-1 reverse transcriptase inhibitors, are reported. In both cases the key-step is based upon the displacement of a 6-methylthio or a 6-tosyl group by nucleophiles according an addition-elimination type mechanism.

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