Add time:08/30/2019         Source:sciencedirect.com

4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA, Compound I) was discovered as the first boronic acid-based class D beta-lactamase inhibitor. It exhibited an IC50 of 5.6 μM against OXA-40. The compound also inhibited class A and C beta-lactamases with sub to low μM IC50, and synergized with imipenem against Acinetobacter baumannii.

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