Add time:08/26/2019         Source:sciencedirect.com

An enantioselective C–H functionalization of N-methoxymethyl (MOM)-protected 2,3-unsubstituted indoles with α-diazopropionates has been effected via catalysis by dirhodium(II) tetrakis[N-phthaloyl-(S)-triethylalaninate], Rh2((S)-PTTEA)4, providing α-methyl-3-indolylacetates in high yields and with enantioselectivities of up to 86% ee. The effectiveness of this protocol was demonstrated by the first catalytic asymmetric synthesis of the (+)-α-methyl-3-indolylacetic acid fragment of acremoauxin A, a potent plant-growth inhibitor. Furthermore, the Fujioka protocol using a combination of TMSOTf and 2,2′-bipyridyl was shown to be superior for the removal of the N-MOM group.

We also recommend Trading Suppliers and Manufacturers of α-Methyl-4-[4-(methoxymethyl)-2-thiazolyl]benzeneacetic acid (cas 138568-66-8). Pls Click Website Link as below: cas 138568-66-8 suppliers