Add time:08/28/2019         Source:sciencedirect.com

A series of N-alkylated glycine and l-alanine bearing oligoethylene glycol (OEG) and benzyl side chains, i.e., N-(4-oligoethylene glycol)benzyl glycine and N-(4-oligoethylene glycol)benzyl alanine (NMe(OEt)xOBnG and NMe(OEt)xOBnA, x=1-3), have been readily synthesized via schiff base and reductive amination reactions. The successful ring opening polymerization (ROP) of N-substituted glycine N-carboxyanhydrides (NCA) results in three types of peptoid oligomers (PNMe(OEt)xOBnG,x=1-3). Depending on the length of OEG side chains, PNMe(OEt)xOBnG show different solubility in water. Particularly, the as-prepared oligomers containing three ethylene glycol units (PNMe(OEt)3OBnG) display interesting thermoresponsive aggregation behaviors in water. DSC results reveal that all the oligomers show crystalline behaviors with melting temperatures decreasing as the OEG side chain length is increased. Both live-dead and MTT assays indicate low cytotoxicity of PNMe(OEt)2OBnG and PNMe(OEt)3OBnG toward HeLa cells, comparable to benchmark PEG. Concerning thermoresponsive and crystalline properties, the as-prepared peptoid oligomers are potentially promising building blocks for stimuli-responsive bioinspired materials and hierarchical self-assembly.

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