Add time:08/25/2019         Source:sciencedirect.com

Epoxidation of 3-methoxy-16-methylene-estra-1,3,5(10)-trien-17-one in the presence of alkaline hydrogen peroxide gives rise to (16R)- and (16S)-spiro[3-methoxy-17-oxoestra-1,3,5(10)-triene-16,2′-oxirane] in similar proprotions. Epoxidation of the corresponding 16-methylene 17μ-alcohol and 16-methylene-17μ-acetate with m-chloroperbenzoic acid does not display any significant direting effects associated with allylic functionally, whereas Sharpless epoxidation of the 16-methylene 17μ-alcohol is highly stereoselectivity, leading exclusively to the (16R) isomer. cis-Hydroxylation of the 16-methylene 17-ketone with osmium tetroxide/ 4-methylmorpholine-4-oxide proceeds stereoselectively to give mainly 16α-hydroxy-16μ-hydroxymethyl-3-methoxyestra-1,3,5(10)-trien-17-one. The isomeric addition products derived from these reactions are correlated by appropariate interconversions, and the assignments are corroborated by comparative reactivity of derived products.

We also recommend Trading Suppliers and Manufacturers of 3-methoxyestra-1,3,5(10),6-tetraen-17-one (cas 17253-36-0). Pls Click Website Link as below: cas 17253-36-0 suppliers