Add time:08/28/2019         Source:sciencedirect.com

Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. Further manipulation afforded benzofurans 6 and 7. Compound 7 was of comparable potency as a glucose and triglyceride lowering agent in insulin resistant rodents to BRL 49653.

We also recommend Trading Suppliers and Manufacturers of (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid (cas 17257-71-5). Pls Click Website Link as below: cas 17257-71-5 suppliers