Add time:08/25/2019         Source:sciencedirect.com

A simple and efficient cascade Michael/cyclization reaction of 3-aminoindolin-2-ones with enones/enals was identified for the synthesis of potentially biologically active 3′,4′-dihydrospiro[pyrrol-3,2′-oxindoles], using DBU as an efficient catalyst and ethylene glycol as an environmentally benign solvent. More diverse 3′,4′-dihydrospiro[pyrrol-3,2′-oxindoles] analog libraries were prepared in good yields (up to 97%). The structure of 3′,4′-dihydrospiro[pyrrol-3,2′-oxindoles] was confirmed by mass spectrometry analysis, NMR analysis and single crystal X-ray diffraction. The main advantages of this method include the availability of starting materials, simple experimental operation, short reaction time, as well as high yields observed.

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