Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2′-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate-Science-Chemical Encyclopedia-lookchem

Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2′-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate
Add time:08/25/2019 Source:sciencedirect.com

An 11-step synthesis of endo,endo-2-amino-6-[(E)-2′-phenyl]ethenylbicyclo[2.2.1]heptane (6) and the corresponding (Z)-isomer (7) was carried out in an attempt to make a compound that could trap the purported amine radical cation intermediate during monoamine oxidase (MAO)-catalyzed oxidation of amines. The E-isomer was not a substrate for MAO, and the Z-isomer was a very poor substrate. No trapping product was observed. Possible explanations for the inability of these compounds to trap a potential radical cation intermediate are discussed.

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