Single-flask polyfunctionalization of the imidazole ring; a streamlined route to the antitumor agent carmethizole-Science-Chemical Encyclopedia-lookchem

Single-flask polyfunctionalization of the imidazole ring; a streamlined route to the antitumor agent carmethizole (cas 117120-88-4)
Add time:08/27/2019 Source:sciencedirect.com

Three sequential treatments of an N-protected tribromoimidazole with n-BuLi / electrophile in a 1-pot process leads to N-protected 2,4,5-trisubstituted imidazoles. The method can be applied to the preparation of the immediate of carmethizole.

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