Add time:07/13/2019         Source:sciencedirect.com

Coupling of chiral 1-O-benzylglycerol-2,3-bistriflate with trilithiated chiral 2-N-Boc-3-phenylsulfonylpropan-1-ol derivative constitutes an efficient route to chiral C-5 substituted prolines which can potentially induce cis Xaa-Pro peptide bond conformation. A straightforward seven-step synthesis of the title compound is described.

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