Add time:08/29/2019         Source:sciencedirect.com

Regioisomeric analogues of gramine, 5-(dialkylaminomethyl)indole-2-carboxylates were prepared by the Fischer indolization of 4-(dialkylaminomethyl)phenylhydrazones easily obtained from diazotized 4-(dialkylaminomethyl)anilines by the Japp–Klingemann reaction. These formal Mannich bases are valuable synthetic intermediates affording 5-(chloromethyl)indoles on reaction with acetyl chloride at rt within a few minutes in quantitative yields.

We also recommend Trading Suppliers and Manufacturers of 5-(CHLOROMETHYL)-N-PHENYL-1,3,4-THIADIAZOLE-2-CARBOXAMIDE (cas 113940-13-9). Pls Click Website Link as below: cas 113940-13-9 suppliers