Biocatalytic synthesis of (2S)-5,5,5-trifluoroleucine and improved resolution into (2S,4S) and (2S,4R) diastereoisomers-Science-Chemical Encyclopedia-lookchem

Biocatalytic synthesis of (2S)-5,5,5-trifluoroleucine and improved resolution into (2S,4S) and (2S,4R) diastereoisomers
Add time:08/25/2019 Source:sciencedirect.com

The introduction of fluorinated amino acid carrying a CF3 moiety in therapeutical agents and protein engineering requires the accessibility of highly pure chiral samples in order to correctly understand the effect of fluorination on bioactivity. Here we report an easy enzymatic approach for the synthesis of (2S)-5,5,5-trifluoroleucine and its subsequent resolution into its (2S,4S) and (2S,4R) diastereoisomers. This strategy stands for a sustainable synthesis and enhanced resolution by means of alternative protecting groups for the amino/acid functionalities than that previously reported.

We also recommend Trading Suppliers and Manufacturers of (2S,4S)-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER (cas 113949-37-4). Pls Click Website Link as below: cas 113949-37-4 suppliers

Prev:Increased binding to sigma sites of N-[1′(2-piperidinyl)ethyl)-4-[I-125]-iodobenzamide (I-125-PAB) with onset of tumor cell proliferation
Next: Fast systematic approach for the determination of drugs in biological fluids by fully automated high-performance liquid chromatography with on-line solid-phase extraction and automated cartridge exchange: Application to Cebaracetam (cas 113957-09-8) in human urine)

Click to view details

Encyclopedia