Structure–activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors-Science-Chemical Encyclopedia-lookchem

Structure–activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors
Add time:08/28/2019 Source:sciencedirect.com

A series of N-methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors. N-Methyl-2-[1-(3-aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide (21) was the most potent inhibitor of H2O2-induced necrotic death of human leukemia HL60 cells among them.

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