Add time:08/30/2019         Source:sciencedirect.com

Background: An inhibitory effect of ascorbic acid (AsA) on melanogenesis has been described. However, AsA is quickly oxidized and decomposed in aqueous solution and thus is not generally useful as a depigmenting agent.Objective: Our purpose was to examine the effect on pigmentation of magnesium-l-ascorbyl-2-phosphate (VC-PMG), a stable derivative of AsA.Methods: Percutaneous absorption of VC-PMG was examined in dermatomed human skin, and its effect on melanin production by mammalian tyrosinase and human melanoma cells in culture was also measured. A 10% VC-PMG cream was applied to the patients.Results: VC-PMG suppressed melanin formation by tyrosinase and melanoma cells. In situ experiments demonstrated that VC-PMG cream was absorbed into the epidermis and that 1.6% remained 48 hours after application. The lightening effect was significant in 19 of 34 patients with chloasma or senile freckles and in 3 of 25 patients with normal skin.Conclusion: VC-PMG is effective in reducing skin hyperpigmentation in some patients.

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