Add time:08/25/2019         Source:sciencedirect.com

The density (ρ), viscosity (η) and conductivity (Ʌ) studies of Aspartic Acid and Glutamic Acid in aqueous solution of Dopamine hydrochloride were carried out at three different temperatures having an interval of 10 K under atmospheric pressure. The experimental data were methodically used to enumerate various thermophysical parameters which assist to gather information about the presence of plausible intermolecular interactions in the ternary (Dopamine hydrochloride + water + amino acids) system. The results were interpreted in terms of various Dopamine hydrochloride-amino acid intermolecular interactions through a cosphere overlap model. In this article, we also focused on spectroscopic methods like UV–Visible, Nuclear Magnetic Resonance spectroscopy and Raman spectroscopy to ensure the nature of drug–amino acid interaction in solution phase. The Benesi-Hildebrand method was used to calculate the binding constants for both the amino acids in ternary system. The Gibbs free energy change of the system was calculated indicating spontaneity of the systems. Hydrogen bonding along with ionic-hydrophilic interactions was observed as significant factors for such interactions. Furthermore, structure making behaviors of both amino acids were detected in aqueous Dopamine hydrochloride. These calculated parameters were found to be sensitive towards the interactions prevailing in DH-amino acids system. Convincingly existence of a good qualitative correlation is observed with regard to DH-Glu interactions obtained from the measurements. The experimental and correlated data could be used in the development of models for mixtures of drug molecules with amino acids.

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