Add time:08/26/2019         Source:sciencedirect.com

The stereocontrolled synthesis of seven 2-substituted-4-carboxy-3,4,5,6-tetrahydropyrimidines bearing either one chiral center at C-4 or two chiral centers at C-4 and C-8 was performed by condensation of (S)- or (R)-2,4-diaminobutyric acid (Daba) with iminoethers derived from glycine, (S)- and (R serine, (S)- and (R)-tyrosine. Under the conditions reported, epimerization was always completely prevented at the C-4 center, whereas at the C-8 center, it was completely avoided in the case of tyrosine derivatives and considerably diminished for the serine derivatives.

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