Add time:08/26/2019 Source:sciencedirect.com
The preparation of aziridine-2,2-dicarboxylates via 1,4-addition of N,O-bis(trimethylsilyl)hydroxylamine to α,β-unsaturated malonates in the presence of chiral Lewis acids is reported. Good enantioselectivity was observed for conjugate addition catalysed by [Cu(S,S)-Bn-(box)](OTf)2 on isobutylidene and 3-methylbutylidene malonate.
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