Add time:09/01/2019         Source:sciencedirect.com

A new and facile procedure was developed to synthesize novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.

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