Add time:07/16/2019         Source:sciencedirect.com

A series of novel 9-benzylideneamino derivatives of homocamptothecin were synthesized via Friedlaender cyclization from our obtained intermediate 5. All the compounds were evaluated for in vitro cytotoxicity against three cancer cell lines (A549, LOVO and MDA-MB-435). Most of these derivatives possessed potent growth inhibitory effect on all the tested cell lines and four compounds (6d, 6f, 6i, 6k) showed higher inhibitory activities with the IC50 values of 2.3 nM–9.8 nM against breast cancer cell than topotecan. As compared to CPT, compound 6f revealed higher topoisomerase I inhibitory activity.

We also recommend Trading Suppliers and Manufacturers of 1-(benzylideneamino)-2,2,2-trichloroethanol (cas 43180-42-3). Pls Click Website Link as below: cas 43180-42-3 suppliers