Add time:08/30/2019         Source:sciencedirect.com

A new series of beta amino acids, which act as CXCR3 antagonists, has been identified. The formerly optimized N,N-disubstituted benzylamine derivatives with carboxylic acid function on the N-atom was used as starting point and compounds with carboxyl function not attached to the N-atom were investigated. Affinity, metabolic stability in human and mouse liver microsomes and Caco-2 permeability were optimized. Compounds with double-digit nanomolar CXCR3 affinity, favourable microsomal stability and Caco-2 permeability have been identified.

We also recommend Trading Suppliers and Manufacturers of 2-Ethyl-2,3-dihydrobenzofuran-2-carboxylic acid (cas 111080-50-3). Pls Click Website Link as below: cas 111080-50-3 suppliers