Add time:08/27/2019         Source:sciencedirect.com

Pd(II)-catalyzed alkenylation of methyl 1-(2-bromoaryl)-3-(2-furyl/thienyl)-5-oxopyrrolidine-2-carboxylate derivatives 1(a–d) resulted in the formation of 3(a–d) exclusively via C–H activation in the heteroaryl moiety. Similar observations were observed for the corresponding diester analogues 4(a–d) to form 5(a–d). Normal Heck reaction, however, was observed in the case of 1(a–f) to furnish 2(a–f) when the reaction was carried out with Pd(0) catalyst generated in situ. Pd(0)-catalyzed vinylation of 4(a–f) via C–Br oxidation, however, failed due to steric reason.

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