Add time:08/31/2019         Source:sciencedirect.com

A series of nitrobenzyl phosphoramide (cas 13597-72-3) mustards and their analogs was designed and synthesized to explore their structure–activity relationships as substrates of nitroreductases from Escherichia coli and trypanosomes and as potential antiproliferative and antiparasitic agents. The position of the nitro group on the phenyl ring was important with the 4-nitrobenzyl phosphoramide mustard (1) offering the best combination of enzyme activity and antiproliferative effect against both mammalian and trypanosomatid cells. A preference was observed for halogen substitutions ortho to benzyl phosphoramide mustard but distinct differences were found in their SAR of substituted 4-nitrobenzyl phosphoramide mustards in E. coli nitroreductase-expressing cells and in trypanosomatids expressing endogenous nitroreductases.

We also recommend Trading Suppliers and Manufacturers of phosphoramide (cas 13597-72-3). Pls Click Website Link as below: cas 13597-72-3 suppliers