Add time:08/29/2019         Source:sciencedirect.com

The synthesis and Myers–Saito type cycloaromatization reactions of 10-membered enediynes containing a sulfone or a sulfoxide moiety are described. These enediynes cycloaromatized smoothly under physiological conditions to generate bioactive α,3-didehydrotoluene biradicals, that showed potent DNA damaging abilities. Further, in the presence of a nucleophile such as amine or sulfide, cycloaromatization did not occur following the radical reaction pathway but ionically induced cycloaromatization took place.

We also recommend Trading Suppliers and Manufacturers of Sulfone, 2-butynyl phenyl, (cas 13603-84-4). Pls Click Website Link as below: cas 13603-84-4 suppliers