Add time:08/26/2019         Source:sciencedirect.com

Hydrocortisone, cortexolone, hydrocortisone-17-butyrate, and budesonide were oxidized into α-ketoaldehydes by air exposure in the presence of Cu(OAc)2. When free hydroxyl functions were present at position 17, hydrocortisone and cortexolone, the formed oxidation products, were identified as hemiacetal dimeric structures involving the free hydroxyl functions at position 17 and the newly formed aldehydes at position 21. Dimeric structures were established by using 1H{13C} correlations (HSQC and HMBC) and 1H1H correlations (COSY and ROESY). The hemiacetal function was further confirmed by reaction of the dimer formed from hydrocortisone with two equivalents of 3-methyl-2-benzotriazolinone hydrazine (MTBH), giving quantitatively two equivalents of the 3-methyl-2-benzotriazolinone hydrazone of 21-dehydrohydrocortisone. When no free hydroxyl function was present as in the case of hydrocortisone-17-butyrate and budesonide, the expected α-ketoaldehydes were obtained.

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