Add time:08/27/2019         Source:sciencedirect.com

Exercise endurance and metabolic patterns were determined in rats that had been administered commercial preparations of “PANGAMIC ACID (cas 12770-30-8),” dimethylglycine, or diisopropylamine subcutaneously. None of these substances affected (a) the time required to reach exhaustion by treadmill running, (b) the specific activities of succinate dehydrogenase of liver and muscle, (c) the capacity of liver mitochondria for oxidative N-demethylation, (d) the content of mitochondria in liver, (e) the ratios of soluble to membranous protein of the liver mitochondria, or (f) the level of urinary excretion of creatinine. The concentrations of glycogen in muscle and liver were not increased. These results do not substantiate previous reports by Russian investigators on whose work many athletes base their practice of consuming pangamate to improve performance.

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