Encyclopedia

  • Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice
  • Add time:08/29/2019         Source:sciencedirect.com

    Hepatic tumor promoting activity was determined for mixtures of dichloroacetic acid (DCA) and trichloroacetic acid (TCA) in female B6C3F1 mice initiated on day 15 of age with 25 mg/kg N-methyl-N-nitrosourea. The mice received in their drinking water from 6 to 50 weeks of age either DCA (7.8, 15.6, or 25 mmol/l) with/without 6.0 mmol/l TCA or TCA (6.0 or 25 mmol/l) with/without 15.6 mmol/l DCA. Proliferative lesions (foci of altered hepatocytes and hepatocellular adenomas) promoted by TCA increased linearly with its concentration and were predominantly basophilic and negative for gtutathione Stransferase-π (GST-π), while those promoted by DCA increased exponentially with its concentration and were eosinophilic and positive for GST-π. The promoting activity of DCA and TCA in mixtures was at least additive. The proliferative lesions resulting from exposure to the mixtures were predominately similar to those promoted by DCA, i.e. contained eosinophilic and GST-π-positive hepatocytes.

    We also recommend Trading Suppliers and Manufacturers of PANGAMIC ACID (cas 12770-30-8). Pls Click Website Link as below: cas 12770-30-8 suppliers


    Prev:The effect of amino acids and related compounds on the metabolism of saliva
    Next: V-Loc™ 180 suture in total laparoscopic hysterectomy: a retrospective study comparing polysorb (cas 12770-88-6) to barbed suture used for vaginal cuff closure)

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View