Add time:09/04/2019         Source:sciencedirect.com

The novel and efficient synthesis of type 2 Lewis antigens is reported in this study. The rationally designed LACTOSAMINE (cas 13000-25-4)-3,2′-diol derivative with an orthogonal set of protecting groups is efficiently glycosylated with a benzyl protected 1-thio-l-fucoside donor in a unique regioselective manner to produce Lewis x (Lex) and Lewis y (Ley) derivatives in good yields. These derivatives can be prepared not only exclusively but also synchronously by choosing the appropriate reaction temperature and donor–acceptor molar ratio. The Lex derivatives are easily converted into sulfated or non-sulfated Lex bearing a terminal azido functionalized oligo-(ethyleneoxide) linker; the Ley derivative having the same linker can also be prepared, all of which can be further used for the chemical modification of other compounds and materials.

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