Add time:08/27/2019         Source:sciencedirect.com

The reaction of 1,4-dichloro-2-butyne with potassium phthalimide yielded N-(4-chloro-2-butynyl)phthalimide, which was subsequently condensed with ethyl acetamidomalonate. Acid hydrolysis of the condensation product gave 2,6-diamino-4-hexynoic acid. Growth inhibition of Leuconostoc dextranicum 8086 by 2,6-diamino-4-hexynoic acid is reversed in a competitive manner by lysine over a hundredfold range of increasing concentrations with an inhibition index of about 10.

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