Add time:09/02/2019         Source:sciencedirect.com

Swinholide A and isoswinholide A were synthesised in 7 steps from the fully protected seco acid 4. Key steps include: (i) bimolecular acylation, 7 + 10 → 12, (ii) selective hydrolysis of the methyl ester, 16 → 17, and (iii) regioselective macrolactonisation. 17 → 18. The monomeric lactone analogues 2 and 5 were prepared by regioselective macrolactonisation of the seco acid 6, where the ring size was controlled by variation of the reaction conditions.

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