Add time:09/01/2019         Source:sciencedirect.com

A short and efficient enantioselective synthesis of the HIV protease inhibitor amprenavir 1 (99% ee) as well as a formal synthesis of saquinavir 3 have been achieved in high enantiomeric purity starting from commercially available materials. Our strategy mainly comprises a Co-catalyzed two-stereocentred hydrolytic kinetic resolution (HKR) of racemic 2-(1-azido-2-phenylethyl)oxirane as the chirality inducing step. Also presented is a concise synthesis of (S)-3-hydroxytetrahydrofuran 4, the key structural feature, in high enantiomeric purity (98% ee).

We also recommend Trading Suppliers and Manufacturers of 2-[1-(1-PHENYLETHYL)-3-AZETIDINYLOXY]PYRIDINE (cas 132924-58-4). Pls Click Website Link as below: cas 132924-58-4 suppliers