Add time:08/30/2019         Source:sciencedirect.com

A green Passerini three-component reaction of 2-(4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid with alkyl or aryl isocyanides and aldehydes was reported under aqueous conditions at 35 °C for 1 h, and 21 indolone-N-amino acid derivatives were prepared in high yields of 42%–99%. Their structures were characterized by IR, ESI–MS, NMR and elemental analysis, and the possible mechanisms have been also proposed. The highly efficient and eco-friendly method provides a facile access to a library of indolone-N-amino acid derivatives for future research on bioactivity screening.

We also recommend Trading Suppliers and Manufacturers of 6-Methyl indole-2-carboxylic acid Methylester (cas 18377-65-6). Pls Click Website Link as below: cas 18377-65-6 suppliers