Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones—a novel class of HIF-hydroxylase inhibitors-Science-Chemical Encyclopedia-lookchem

Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones—a novel class of HIF-hydroxylase inhibitors
Add time:09/02/2019 Source:sciencedirect.com

The synthesis of various substituted 2-pyridyl-5-cyano-pyrimidine-6-ones was accomplished via a three-step protocol. The key aspects of this parallel protocol was the preparation of amidines from nitriles under mild conditions followed by cyclization with ethyl (ethoxymethylene)cyanoacetate.

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