Add time:09/01/2019         Source:sciencedirect.com

A simple and efficient one-pot two-step synthesis of substituted 3-aminoarylquinolines has been achieved from 2-nitrobenzaldehyde and Indole (cas 120-72-9)s under microwave irradiation. Firstly 2-nitrobenzaldehydes is reduced to 2-aminobenzaldehyde in situ by commonly used chemo selective reductant SnCl2 followed by condensation of indole. The acidic nature of the resultant reaction mixture due to SnCl2 helps in the condensation and facile ring opening of indole leading to the formation of 3-aminoarylquinoline derivatives in good to moderate yields.

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