Add time:09/02/2019 Source:sciencedirect.com
High-resolution capillary gas chromatography-mass spectrometry with selective ion monitoring and using deuterated 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) (BHA) as an internal standard was used to measure BHA in the plasma and urine of human volunteers after oral administration of 30 or 5 mg of the compound in olive oil. Pharmacokinetic studies showed similar plasma-concentration profiles in subjects treated with either level of BHA. About 20% of the administered dose was excreted as BHA glucuronide in the urine within the first 24 hr.
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