Add time:08/28/2019 Source:sciencedirect.com
A general method for the synthesis of 6-position modified lincosamines via stereospecific nucleophilic addition to readily available galactose 6-nitrone has been developed. A new route for the stereospecific installation of thioalkyl groups at the 1-position was also developed. These methods allow access to a variety of new derivatives of antibacterial lincosamides.
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