Add time:09/02/2019 Source:sciencedirect.com
A two-carbon homologation-amination technology of aldehydes is described. Key steps involve the Michael-type addition of a nitrogen nucleophile (benzylamine, trimethylsilylazide, potassium phtalimide) to a 2-alkenyl N-methylthiazolium salt obtained by olefination of the aldehyde with the phosphorane (1), and the thiazole-to-formyl deblocking. The addition of benzylaminine to the thiazolium salt derived from the acetonide of D- glyceraldehyde occurs with a good level of syn-diastereoselectivity (ds, 85-90 %) in agreement with a modified Felkin-Anh model. This technology is employed in short synthetic routes to D-3-epi-daunosamine from 4-deoxy D-threose and some lincosamine (cas 13006-69-4) analogues from α-D-dialdogalactopyranose.
We also recommend Trading Suppliers and Manufacturers of lincosamine (cas 13006-69-4). Pls Click Website Link as below: cas 13006-69-4 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View