Add time:09/01/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the synthesis, methods of analysis, and physical properties of mafenide acetate. Mafenide is a synthetic anti-infective agent that is closely related to sulfonamides in its chemical composition; it differs structurally from sulfonamides in that it contains a methylene group between the benzene ring and the amino nitrogen of a basic sulfonamide structure. Mafenide is normally obtained as an acetate salt. The action of mafenide is primarily bacteriostatic. Unlike other sulfonamides, it does not compete with the essential bacterial metabolite p-aminobenzoic acid. Even though the exact mechanism of the antibacterial activity of mafenide is not known, it has been shown that a marked inhibition of protein synthesis occurs at the drug concentrations that are used in the treatment of burn wounds.

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