Add time:09/04/2019         Source:sciencedirect.com

5α-Cholest-8(14)-en-3β,9α-diol-15-one has been prepared by chemical synthesis in two steps from 5α-cholest-8(14)-en-3β-ol-15-one. 9α-Fluoro-5α-cholest-8(14)-en-3β-ol-15-one was prepared in 91% yield from the corresponding 9α-hydroxysterol. 9α-Fluoro-5α-cholest-8(14)-en-3,15-dione was prepared, in 84% yield, from the corresponding 3β-hydroxy compound. These compounds have been found to be potent inhibitors of sterol synthesis in animal cells in culture. The concentrations of the steroids required to cause a 50% inhibition of the synthesis of digitonin-precipitable sterols from labeled acetate were comparable to those required to cause a 50% reduction in the levels of HMG-CoA reductase activity in the same cells.

We also recommend Trading Suppliers and Manufacturers of cholest-8(14)-ene-3,26-diol-15-one (cas 114182-43-3). Pls Click Website Link as below: cas 114182-43-3 suppliers