Add time:08/30/2019         Source:sciencedirect.com

The repeated administration of phencyclidine (PCP, 72 mg/kg/day) to rats led to physical dependence, as evidenced by a withdrawal syndrome exhibited approx. 24–48 h following suspension of drug. All components of the withdrawal syndrome were suppressed by s.c. injections of PCP (16 mg/kg), (±)-N-allylnormetazocine (SKF-10047 (cas 133005-41-1), 16 mg/kg) and (+)-SKF-10047 (16 mg/kg), but not by injections of saline or (−)-SKF-10047. Moreover, tolerance to the behavioral effects of PCP, as well as cross-tolerance to (±)-SKF-10047 and (+)-SKF-10047 were observed. These data indicate that PCP and the sigma opiate SKF-10047 share mechanisms of action, which are mediated by the (+)-isomer of the sigma agonist.

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