Add time:08/29/2019         Source:sciencedirect.com

This letter presents synthesis and structure-activity relationship study of sulfonamide derivatives as inhibitors of Human Uric Acid Transporter 1 (hURAT1). Among all tested sulfonamide derivatives, compounds 9b, 16i and 19b exhibited excellent inhibition activity with IC50 value of 10, 2, and 83 nM, respectively. In addition, compounds 9b and 19b demonstrated moderate PK profile in rats.

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